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  • Title: [Complex compounds of heparin in obstetric hemorrhages].
    Author: Kudrjashov BA, Bloshansky UM, Polol'skaya OV, Lyapina LA, Kaverina KP, Spoludennaya ST.
    Journal: Vopr Med Khim; 1975; 21(5):531-8. PubMed ID: 1082678.
    Abstract:
    The so-called uncontrollable hemorrhage in obstetric patients correlated mainly with appearance in blood of complex heparin compounds, primarily fibrinogen-heparin, adrenaline-heparin, noradrenaline-heparin and, less frequently, plasminogen-heparin. The heparin complexes were observed in circulation when the anticoagulation system was stimulated due to appearance of thrombin in the blood stream. The complexes possessed and anticoagulation and antipolymerization effects on fibrin-monomer and caused nonenzymatic lysis of unstabilized fibrin clots.
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