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  • Title: Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.
    Author: Vohora D, Pal SN, Pillai KK.
    Journal: Life Sci; 2000 Apr 21; 66(22):PL297-301. PubMed ID: 10834305.
    Abstract:
    The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide significantly protected clonic seizures induced by PTZ in a dose-dependent manner. The effect of thioperamide was completely countered by pretreatment with R (alpha)-methylhistamine (RAMH), a selective H3-receptor agonist suggesting that the observed effect of thioperamide was elicited by histamine H3-receptors. RAMH alone did not significantly modify PTZ seizures. The findings are consistent with a role for the histaminergic neuronal system in seizures and suggest that H3-receptors may play an important role in modulating clonic seizures induced by PTZ in mice.
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