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  • Title: The Saccharomyces cerevisiae centromere protein Slk19p is required for two successive divisions during meiosis.
    Author: Zeng X, Saunders WS.
    Journal: Genetics; 2000 Jun; 155(2):577-87. PubMed ID: 10835382.
    Abstract:
    Meiotic cell division includes two separate and distinct types of chromosome segregation. In the first segregational event the sister chromatids remain attached at the centromere; in the second the chromatids are separated. The factors that control the order of chromosome segregation during meiosis have not yet been identified but are thought to be confined to the centromere region. We showed that the centromere protein Slk19p is required for the proper execution of meiosis in Saccharomyces cerevisiae. In its absence diploid cells skip meiosis I and execute meiosis II division. Inhibiting recombination does not correct this phenotype. Surprisingly, the initiation of recombination is apparently required for meiosis II division. Thus Slk19p appears to be part of the mechanism by which the centromere controls the order of meiotic divisions.
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