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  • Title: Waldenstrom macroglobulinemia presenting as a pleural effusion.
    Author: Mansoor A, Wagner RP, DePalma L.
    Journal: Arch Pathol Lab Med; 2000 Jun; 124(6):891-3. PubMed ID: 10835529.
    Abstract:
    We describe a patient with Waldenstrom macroglobulinemia who presented with a lymphocytic pleural effusion. Pleural involvement in Waldenstrom macroglobulinemia is very rare. In addition, to our knowledge, there are no reports in the literature in which a primary diagnosis was made on the basis of pleural fluid analysis. The presence of small lymphocytes in serous cavity fluid can pose great difficulty in the differentiation between a low-grade lymphoproliferative disorder and reactive lymphocytosis. The diagnosis of malignancy in this case was established on the basis of morphologic testing, flow cytometry, and the detection of B-cell immunoglobulin gene rearrangement.
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