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  • Title: Single-motor mechanics and models of the myosin motor.
    Author: Yanagida T, Esaki S, Iwane AH, Inoue Y, Ishijima A, Kitamura K, Tanaka H, Tokunaga M.
    Journal: Philos Trans R Soc Lond B Biol Sci; 2000 Apr 29; 355(1396):441-7. PubMed ID: 10836497.
    Abstract:
    Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.
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