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  • Title: Fluvastatin increases prostacyclin and decreases endothelin production by human umbilical vein endothelial cells.
    Author: Seeger H, Mueck AO, Lippert TH.
    Journal: Int J Clin Pharmacol Ther; 2000 May; 38(5):270-2. PubMed ID: 10839471.
    Abstract:
    Fluvastatin, an agent of a class of lipid-lowering drugs, the "statins", significantly enhanced prostacyclin synthesis at the concentrations of 0.1 microM and 1 microM and significantly reduced endothelin production at the concentrations 0.01, 0.1 and 1 microM in cell cultures of human umbilical endothelial veins. Since prostacyclin is a vasodilator and endothelin a vasoconstrictor, fluvastatin may have a significant effect on hemodynamics by favoring the balance towards vasodilation. This mechanism may contribute to the prevention of cardiovascular diseases.
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