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  • Title: [Quantitative characteristics of the phenomenon of acceleration of hematopoiesis regeneration in thymocyte transplantation].
    Author: Zimin IuI, Fedotova MI.
    Journal: Biull Eksp Biol Med; 1975 Jul; 80(7):28-30. PubMed ID: 1084169.
    Abstract:
    Experiments were conducted on hybrid mice (CBA X C57BL) F1. The quantitative characteristics of the phenomenon of acceleration of postirradiation bone marrow regeneration in transplantation of syngenous thymocytes was given. It was revealed that in the range of 10(6)--10(8) cells the effect was independent of the number of transplanted thymocytes. The transplantation during the first 12 hours after the irradiation was equally effective from the aspect of stimulation of the bone marrow restoration. This phenomenon was not expressed under the following conditions: a) transplantation of thymocytes 24 hours after irradiation; b) irradiation of recipients in a dose of 600--700 R; c) irradiation of a thymocyte suspension in vitro in a dose of 10 kR with a subsequent incubation at 37 degrees C for 6--7 hours; d) irradiation of thymocytes in vitro in a dose of 200 kR.
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