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  • Title: [Immunologic competence of T- and B-lymphocytes in tolerance induced by cyclophosphamide].
    Author: Fontalin LN, Novikova TK, Kondrat'eva IA, Pevnitskiĭ LA.
    Journal: Biull Eksp Biol Med; 1976; 81(4):445-7. PubMed ID: 1084175.
    Abstract:
    A study was made of immunological competence of T- and B-lymphocytes of mice subjected to tolerogenic treatment (administration of a massive dose of sheep erythrocytes and cyclophosphamide 7 days before the experiment). The capacity of lymphocytes of tolerant mice to influence the interaction of normal T- and B-lymphocytes was also investigated. This form of tolerance was caused not by T-suppressors, but by a true deficiency of T-cells-helpers (both in the thymus and in the spleen), and partially of B-cells (in the spleen). Some lack of B-cells in the bone marrow was connected with a nonspecific action of cyclophosphamide. Cyclophosphamide is supposed to selectively eliminate cells proliferating in response to the antigen.
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