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  • Title: Role of DBP in the circadian oscillatory mechanism.
    Author: Yamaguchi S, Mitsui S, Yan L, Yagita K, Miyake S, Okamura H.
    Journal: Mol Cell Biol; 2000 Jul; 20(13):4773-81. PubMed ID: 10848603.
    Abstract:
    Transcript levels of DBP, a member of the PAR leucine zipper transcription factor family, exhibit a robust rhythm in suprachiasmatic nuclei, the mammalian circadian center. Here we report that DBP is able to activate the promoter of a putative clock oscillating gene, mPer1, by directly binding to the mPer1 promoter. The mPer1 promoter is cooperatively activated by DBP and CLOCK-BMAL1. On the other hand, dbp transcription is activated by CLOCK-BMAL1 through E-boxes and inhibited by the mPER and mCRY proteins, as is the case for mPer1. Thus, a clock-controlled dbp gene may play an important role in central clock oscillation.
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