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  • Title: Rox1 mediated repression. Oxygen dependent repression in yeast.
    Author: Kastaniotis AJ, Zitomer RS.
    Journal: Adv Exp Med Biol; 2000; 475():185-95. PubMed ID: 10849660.
    Abstract:
    For a large number of oxygen-regulated genes in the facultative aerobe, Saccharomyces cerevisiae, the presence of oxygen is sensed through the ability to use oxygen for heme biosynthesis. Heme induces the transcription of oxygen-induced genes and represses the transcription of hypoxic genes. Repression is mediated by the Rox1 protein in conjunction with the Ssn6/Tup1 general repression complex. The differential repression of hypoxic genes results from a combination of the tightness of Rox1 binding to the regulatory region of specific hypoxic genes and the presence or absence of binding sites for Mot3 which enhances Rox1 repression.
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