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  • Title: Effect of GABAergic compounds on the anion-sensitive Mg2+-ATPase from bream (Abramis brama L.) brain.
    Author: Menzikov SA, Menzikova OV.
    Journal: Biochemistry (Mosc); 2000 May; 65(5):622-6. PubMed ID: 10851043.
    Abstract:
    Preincubation of plasma membranes from bream brain with 10-8-10-4 M gamma-aminobutyric acid (GABA) or muscimol increased the anion-sensitive Mg2+-ATPase activity. The activating effect of neurotransmitters on the Mg2+-ATPase is enhanced with increasing preincubation time of the membranes with the ligands, decreases with increasing Mg2+-ATP concentration in the incubation medium, and is inhibited in the presence of the GABAa-receptor antagonist, bicuculline (90 microgr;M). The anions Cl-, Br-, and I- stimulate the basal Mg2+-ATPase activity, and an effect of 10-4 M GABA in the presence of anions was not found. It is supposed that GABAergic chemicals modify the anion-sensitive Mg2+-ATPase in a receptor-dependent way.
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