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  • Title: Downregulation of G protein-coupled receptors.
    Author: Tsao P, von Zastrow M.
    Journal: Curr Opin Neurobiol; 2000 Jun; 10(3):365-9. PubMed ID: 10851176.
    Abstract:
    Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.
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