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  • Title: [Relationship between T- and B-lymphocyte cooperation and their syngeneity].
    Author: Fontalin LN, Novikova TK, Pevnitskiĭ LA, Kondrat'eva IA.
    Journal: Biull Eksp Biol Med; 1976 Mar; 81(3):325-7. PubMed ID: 1085176.
    Abstract:
    Cooperation efficiency of (CBA x C57BL/6) F1 thymocytes and CBA bone marrow cells in immune response to SRBC was compared with the syngenic combination of the same cells. Selectivity of interaction of the T- and B-lymphocytes of different origin was studied in incomplete cyclophosphamines (CBA x C57BL/6) leads to CBA chimerae, where donors were primed with SRBC and the recipients were either intact or tolerant to the given antigen. F1 T-cells proved to interact with the CAB-B-cells 10-15 times less effectively than with the syngenic B-cells. It is suggested that similarity between the antigenic structure of the cell membrane of the T- and B-lymphocytes, aiding their physical contact, increased the action efficiency of the T-mediator on the B-cell.
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