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  • Title: [How can "significance" and "relevance" be combined?].
    Author: Windeler J, Conradt C.
    Journal: Med Klin (Munich); 2000 May; 95(1 Spec No):68-71. PubMed ID: 10851851.
    Abstract:
    Clinical trials are aimed at providing results which enable improvements in patient care. It is widely criticized, however, that the characterization of results as "significant" or "non-significant" does not allow any assessment of their clinical relevance. To counter this criticism 2 biostatistical concepts are available: the use of confidence intervals and the application of statistical tests with shifted null-hypotheses. Possibilities and limitations of these concepts are discussed in this contribution.
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