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  • Title: Inhibition of neuraminidase with neuraminic acid C-glycosides.
    Author: Wang Q, Wolff M, Polat T, Du Y, Linhardt RJ.
    Journal: Bioorg Med Chem Lett; 2000 May 01; 10(9):941-4. PubMed ID: 10853664.
    Abstract:
    Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15-30 microM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.
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