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Title: [Neonatal hyperthyroidism in a premature infant born to a mother with Grave's disease]. Author: Nicaise C, Gire C, Brémond V, Minodier P, Soula F, d'Ercole C, Palix C. Journal: Arch Pediatr; 2000 May; 7(5):505-8. PubMed ID: 10855389. Abstract: BACKGROUND: Neonatal thyrotoxicosis is most commonly due to transplacental transfer of maternal thyroid-stimulating hormone receptor antibodies (TRAb). Bioassay of thyrotropin receptor antibodies may help to determine the risk for neonatal hyperthyroidism. CASE REPORT: Thyrotoxicosis developed in a premature infant born to a mother with Graves' disease, with a low level of TRAb by bioassay. The infant was treated with carbimazole for two months, until TRAb had disappeared. CONCLUSION: Bioassay TRAb is not always reliable for predicting the development of neonatal hyperthyroidism in infants born to mothers with Graves' disease. Thyroid function should be measured in all these neonates.[Abstract] [Full Text] [Related] [New Search]