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  • Title: Idiopathic sudden sensorineural hearing loss: temporal bone histopathologic study.
    Author: Vasama JP, Linthicum FH.
    Journal: Ann Otol Rhinol Laryngol; 2000 Jun; 109(6):527-32. PubMed ID: 10855562.
    Abstract:
    We microscopically examined the temporal bones of 12 ears with idiopathic sudden sensorineural hearing loss (iSSNHL), 10 ears with presbycusis, 11 ears with normal hearing, and 8 unaffected contralateral ears of patients with iSSNHL. The degeneration of the spiral ligament, vascular stria, hair cells, dendrites, and apical spiral ganglion cells was greater in ears with iSSNHL than in the other groups. The apical ganglion cells were significantly more affected than the basal ganglion cells, and the spiral ganglion cell loss increased as a function of duration of iSSNHL. Cochlear ossification was found in 1 ear with iSSNHL, and hydrops in 2. These findings suggest a viral rather than a vascular or ruptured inner ear membrane origin for iSSNHL.
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