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Title: A microdialysis study on the mechanism of action of gabapentin. Author: Timmerman W, Bouma M, De Vries JB, Davis M, Westerink BH. Journal: Eur J Pharmacol; 2000 Jun 09; 398(1):53-7. PubMed ID: 10856447. Abstract: To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular gamma-aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K(+)-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin.[Abstract] [Full Text] [Related] [New Search]