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  • Title: Lytic infection by double-strand DNA viruses and cell cycle alterations.
    Author: Maréchal V, Piolot T.
    Journal: Pathol Biol (Paris); 2000 Apr; 48(3):289-300. PubMed ID: 10858961.
    Abstract:
    Polyomaviruses, papillomaviruses, adenoviruses and herpesviruses are double-stranded DNA viruses that replicate in the nucleus of the cells they infect and have evolved various strategies to create a cellular environment that is optimally conducive to their replication. One of these strategies consists of activating cellular genes, mostly S-phase genes that are required for the replication of the viral genome. Concomitantly, they encode one or several proteins that negatively regulate the response of the cell to viral infection, notably cell cycle arrest and/or apoptosis. As a result, these viruses profoundly alter the biochemical pathways that normally control cellular growth, and may thus promote uncontrolled cell proliferation. This review describes some well-known mechanisms of cell cycle alteration induced by these viruses.
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