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  • Title: [Significance and expression of insulin-like growth factor II and its receptor in hepatocellular carcinogenesis].
    Author: Fan Z, Yang D, Qin H.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2000 Apr; 8(2):84-6. PubMed ID: 10861110.
    Abstract:
    OBJECTIVE: To provide information on the potential role of insulin-like growth factor II (IGF-II) and insulin-like growth factor II receptor (IGF-IIR) during different liver diseases and hepatocarcinogenesis. METHODS: Southern hybridization was used to detect HBV DNA integration in various kinds of liver tissues, and DNA-RNA in situ hybridization to observe and analyze the mRNA of IGF-II and IGF-II receptor in chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). RESULTS: The expression of IGF-II and IGF-II receptor mRNA was observed not only in HCC, but also in chronic hepatitis and cirrhosis. An increasing gradient of IGF-II and IGF-IIR Mrna expression was in turn from chronic hepatitis (33. 3%), HCC (66.7%) to cirrhosis (72.0%). Strongly positive expression was found in liver cell dysplasia, regenerative nodules and poorly differentiated HCC cells. CONCLUSION: IGF-II and its receptor might play an important role in the development of HCC.
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