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  • Title: Mechanical stress regulation and proliferation of rat mandibular condylar chondrocytes in vitro.
    Author: Yang H, Luo S.
    Journal: Chin J Dent Res; 1999 May; 2(2):54-7. PubMed ID: 10863408.
    Abstract:
    OBJECTIVE: To study the proliferative changes of cultured rat mandibular condylar chondrocytes effected by mechanical stress. METHOD: Flow cytometry (FCM) was used to explore the changes of cellular DNA content and cell cycles of passaged condylar chondrocytes. RESULTS: FCM results indicated that proliferation of cultured rat mandibular condylar chondrocytes decreased with stress duration, with marked differences between the experimental and control groups. CONCLUSION: Within given force duration and force range (0-207 g/an2), proliferation of rat mandibular condylar chondrocytes increased with force magnitude, reaching the maximum 6 hours after application of stress. Cellular proliferation decreased when the chondrocytes were cultured under continuous stress for 24 hours. The mechanism for these proliferation changes requires further study.
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