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  • Title: Incidence of ampicillin-resistant Hemophilus influenzae in otitis media.
    Author: Syriopoulou V, Scheifele D, Howie V, Ploussard J, Sloyer J, Smith AL.
    Journal: J Pediatr; 1976 Nov; 89(5):839-41. PubMed ID: 1086351.
    Abstract:
    Ampicillin resistance in Hemophilus influenzae type b causing serious infections is appreciated, but little is known about ampicillin resistance in nonencapsulated strains causing otitis media. The ampicillin sensitivity of 984 middle-ear isolates of H. influenzae from children in Huntsville, Ala. obtained from 1970-1976, was examined: Nine AmpR isolates were found: one in 1973, two in 1974, three in 1975, and three in the first five months of 1976. Seven strains were nonencapsulated; two were type b. All nine produced beta-lactomase. The incidence of ampicillin resistance in strains causing otitis media increased from 0.6% in 1973 to 2.4% in 1976. AmpR H. influenzae infection should be suspected in situations where ampicillin therapy of otitis media is unsuccessful.
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