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  • Title: A new steroidal saponin from the leaves of Agave americana.
    Author: Yokosuka A, Mimaki Y, Kuroda M, Sashida Y.
    Journal: Planta Med; 2000 May; 66(4):393-6. PubMed ID: 10865469.
    Abstract:
    A new bisdesmosidic spirostanol saponin, along with three known saponins, were isolated from Agave americana (Agavaceae). The structure of the new saponin was elucidated as (25R)-3 beta,6 alpha-dihydroxy-5 alpha-spirostan-12-one 3,6-di-O-beta-D-glucopyranoside. Among the isolated saponins, hecogenin tetraglycoside showed cytotoxic activity against HL-60 human promyelocytic leukemia cells with an IC50 value of 4.3 micrograms/mL.
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