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  • Title: (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.
    Author: Gasparini F, Inderbitzin W, Francotte E, Lecis G, Richert P, Dragic Z, Kuhn R, Flor PJ.
    Journal: Bioorg Med Chem Lett; 2000 Jun 05; 10(11):1241-4. PubMed ID: 10866390.
    Abstract:
    A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.
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