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  • Title: Lysosomal acid phosphatase: difference between normal and chronic lymphocytic leukaemia T and B lymphocytes.
    Author: Meusers P, König E, Fink U, Brittinger G.
    Journal: Blut; 1976 Nov; 33(5):313-8. PubMed ID: 1086689.
    Abstract:
    Lysosomal acid phosphatase was assayed in homogenates of isolated normal and B cell type chronic lymphocytic leukaemia (B-CLL) T and B lymphocytes by biochemical means. Unlike the results of cytochemical studies reported in the literature enzyme activity was considerably higher in normal B lymphocytes than in corresponding T cells. This finding offers the possibility to use acid phosphatase as a marker for normal B lymphocytes. The diminution of acid phosphatase in unseparated B-CLL lymphocytes depends predominantly upon a loss of enzyme activity in the B cell fraction indicating an intrinsic abnormality of these neoplastic lymphocytes.
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