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  • Title: Spontaneous regression of low-grade astrocytomas in childhood.
    Author: Schmandt SM, Packer RJ, Vezina LG, Jane J.
    Journal: Pediatr Neurosurg; 2000 Mar; 32(3):132-6. PubMed ID: 10867559.
    Abstract:
    An 8-year-old boy with neurofibromatosis type 1 (NF1) and a biopsy-proven juvenile pilocytic astrocytoma of the hypothalamic/chiasmatic region was followed with serial MRIs over 4 years. Spontaneous tumor regression was followed by progression and biopsy; 6 months later, the tumor regressed again. This bimodal regression is rare, but highlights the variable natural history of low-grade gliomas in children with NF1 and the difficulty in evaluating response of such tumors to therapy.
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