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  • Title: [Development of a new method for preparing biologically active compounds based on the typed strain Streptomyces werraensis].
    Author: Rusanova EP, Alekhov TA, Fedorova GB, Katrukha GS.
    Journal: Prikl Biokhim Mikrobiol; 2000; 36(3):312-6. PubMed ID: 10867951.
    Abstract:
    The regulatory function of a DNA fragment responsible for actinomycin resistance in the typed strain Streptomyces werraensis ATCC 1365, which produces a macrotetrolide antibiotic, was studied. Metabolic changes made this strain capable of producing an antibiotic complex, which comprises four biologically active compounds absent from the parent culture.
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