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  • Title: [HLA-B27 in Bechterew's disease].
    Author: Ulvestad E.
    Journal: Tidsskr Nor Laegeforen; 2000 Apr 30; 120(11):1317-22. PubMed ID: 10868094.
    Abstract:
    BACKGROUND: The role of HLA-B27 in rheumatic disease is reviewed. MATERIAL AND METHODS: The PubMed database was searched for the code words HLA-B27, ankylosing spondylitis, or their combinations. The diagnostic value of HLA-B27 for ankylosing spondylitis was calculated using Bayes' theorem. RESULTS: It is still not clear whether HLA-B27 is a contributing causal factor for ankylosing spondylitis and reactive arthritis. Knowledge of a patient's HLA-B27 status for establishing prognostic information is of uncertain clinical value. INTERPRETATION: Knowledge of HLA-B27 status has limited diagnostic value. HLA-B27 status is clinically most informative when the test result is negative, as ankylosing spondylitis can be ruled out.
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