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  • Title: [Assessment of the reinforcing properties of self stimulation in rats using the "discordance" index].
    Author: Grigor'ian GA, Meshcherskiĭ RM.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1976; 26(5):1001-10. PubMed ID: 1087088.
    Abstract:
    Histogramms of the duration of pedal pressing (PDH) as a function of stimulation parameters, were studied in fifteen rats with electrodes inserted in the lateral hypothalamus and with fixed series of brain stimulation. The "discordance" parameter was used to estimate the changes in PDH modes relative to the moment of the end of brain stimulation. It was found that an increase in the stimulation charge brought about a gradual replacement of positive discordance (the duration of pressing exceeds that of stimulation) by a negative one (duration of pressing is shorter than that of stimulation) and a rise of negative discordance. It is assumed that in the case of positive discordance the duration of the total brain stimulation possesses reinforcing properties, while in the case of negative discordance the beginning of the stimulation possesses reinforcing properties, and its continuation becomes negative.
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