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  • Title: Re-evaluation of the role of aldosterone in mechanism of natriuresis induced by extracellular fluid volume expansion.
    Author: Turek R, Ponec J, Brlicová A, Lichardus B.
    Journal: Endocrinol Exp; 1976; 10(4):253-7. PubMed ID: 1087225.
    Abstract:
    Acute experiments were performed in thiobarbiturate (Inactin, PROMONTA) anaesthesia in 21 male rats. It was found that the attenuation of the antinatriuretic effect of aldosterone by a spironolactone Aldactone (BOEHRINGER) in a dose of 10 mg per rat in 1 h i.v. enhanced urine (V) and sodium (UNaV) excretion following the extracellular fluid volume expansion (ECFV) with intravenous infusion of saline. Max. V = 81.44 +/- +/- 7.46 mul min-1 was obtained in Aldactone treated rats as compared to 54.95 + 7.24 mul min-1 in controls: UNaV = 9.89 +/- 1.26 muval min-1 vs. 6.17 +/- 0.73 muval min-1, respectively. The urinary Na/K ratio was also significantly higher in the same samples of Aldactone treated rats (6.15 +/- +/- 1.22 vs. 2.68 +/- 0.19). It is concluded that endogenous aldosterone blunts nriuresis induced by the ECFV expansion.
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