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  • Title: Determination of grepafloxacin in plasma and urine by a simple and rapid high-performance liquid chromatographic method.
    Author: Kamberi M, Kamberi P, Nakano S.
    Journal: J Chromatogr B Biomed Sci Appl; 2000 May 12; 741(2):295-300. PubMed ID: 10872599.
    Abstract:
    A rapid, specific, sensitive and economical method has been developed and validated for the determination of grepafloxacin in human plasma and urine. The assay consisted of reversed-phase HPLC with UV detection. Plasma proteins were removed by a fast and efficient procedure that has eliminated the need for costly extraction and evaporation. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a reversed-phase TSK gel column with an isocratic mobile system. The method had a quantification limit of 0.05 microg/ml in plasma and 0.5 microg/ml in urine. The coefficients of variation (C.V.) were less than 4% for within- and between-day analyses. The method was successfully applied to a pharmacokinetic study, and was proved to be simple, fast and reproducible.
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