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  • Title: Identification, gene structure, and expression of human frizzled-3 (FZD3).
    Author: Sala CF, Formenti E, Terstappen GC, Caricasole A.
    Journal: Biochem Biophys Res Commun; 2000 Jun 24; 273(1):27-34. PubMed ID: 10873558.
    Abstract:
    We report the identification, genomic structure, chromosomal localization, and expression analysis of human frizzled-3 (FZD3), a 7-transmembrane receptor belonging to the frizzled family. The cDNA obtained from adult human brain shows 91% identity at the nucleotide level and 98% at the amino acid level to mouse frizzled-3 (fzd3). The FZD3 locus is located on chromosome 8p21, spans 48 Kb and its coding sequence is distributed in 6 exons intercalated by 5 introns. FZD3 is expressed in all analyzed human tissues, with quantitatively higher expression in the CNS and in urogenital structures.
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