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  • Title: [Acute toxic accident following lumbar plexus block with bupivacaine].
    Author: Pham-Dang C, Beaumont S, Floch H, Bodin J, Winer A, Pinaud M.
    Journal: Ann Fr Anesth Reanim; 2000 May; 19(5):356-9. PubMed ID: 10874433.
    Abstract:
    We report the case of a patient who experienced ventricular dysrhythmias and seizure five minutes after the injection of 30 mL of 0.5% bupivacaine with 1:200,000 epinephrine, during a lumbar plexus block performed via the posterior approach described by Winnie. The patient who underwent his total hip arthroplasty was still anaesthetised and under controlled ventilation at the time of bupivacaine administration. Aspiration test performed before injection was negative. Normal cardiac activity and stable haemodynamic condition were restored after one hour of resuscitation including 15 electric shocks and administration of epinephrine (40 mg) and clonidine (300 micrograms). The patient was discharged without neurologic sequelae after four days in the ICU.
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