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  • Title: [Cutaneous, hepatic and hematologic manifestations due to nevirapine: DRESS syndrome?].
    Author: Sissoko D, Ajana F, de la Tribonnière X, Baclet V, Mouton Y.
    Journal: Presse Med; ; 29(19):1041-2. PubMed ID: 10874910.
    Abstract:
    BACKGROUND: Manifestations similar to DRESS syndrome (drug rash with eosinophilia and systemic symptoms) may be induced by nevirapine. CASE REPORTS: Three patients developed skin rash and general signs of liver dysfunction during the first 5 weeks after starting nevirapine. Laboratory tests showed elevated eosinophil counts and signs of inflammation simulating severe infection. DISCUSSION: The incidence of DRESS syndrome is probably underestimated. No standard treatment has been proposed. In our 3 patients, parenteral corticosteroid therapy was successful, leading to a rapidly favorable clinical course although liver tests took longer to return to normal.
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