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  • Title: Involvement of nitric oxide from nerves on diarrhea induced by castor oil in rats.
    Author: Uchida M, Kato Y, Matsueda K, Shoda R, Muraoka A, Yamato S.
    Journal: Jpn J Pharmacol; 2000 Feb; 82(2):168-70. PubMed ID: 10877537.
    Abstract:
    Nitric oxide (NO) is involved in the mechanism of castor oil-induced diarrhea. This study was performed to elucidate the source of NO. Diarrhea was induced by oral administration of castor oil in rats. Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole. This effect was attenuated by the treatment with L-arginine. Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea. N(G)-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats. These data suggest, at least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.
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