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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: VHL takes HIF's breath away.
    Author: Krek W.
    Journal: Nat Cell Biol; 2000 Jul; 2(7):E121-3. PubMed ID: 10878820.
    Abstract:
    Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
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