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  • Title: Neonatal lupus erythematosus.
    Author: Corona R, Angelo C, Cacciaguerra MG, Conti G, De Pità O, Coletti V, el Hachem M, Paradisi M.
    Journal: Cutis; 2000 Jun; 65(6):379-81. PubMed ID: 10879307.
    Abstract:
    Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous to those of adult subacute cutaneous lupus erythematosus, or both. We report a case of NLE in a 3-month-old male infant, born to a clinically asymptomatic mother, presenting small, annular, erythematous plaques with sharp, hyperkeratotic borders and central clearing localized at the eyebrow region. Both the infant and the mother were positive for anti-Ro(SS-A).
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