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  • Title: [Acid-base balance in ulcer patients].
    Author: Malov IuS, Ivashkina TG, Kulikov AN, Rossolovich AP.
    Journal: Klin Med (Mosk); 2000; 78(5):31-4. PubMed ID: 10881506.
    Abstract:
    Acid-base balance was studied in 60 ulcer patients in exacerbation and after treatment with losek and blockers of H2-histamine receptors. In exacerbation, all the patients had acidosis of metabolic or respiratory type. Losek changed blood pH insignificantly, and one acidosis type changed for the other. A single ranitidin dose shifted pH to alkalosis in healthy subjects while ulcer patients given famotidine restored acid-base balance. The latter is shown to correlate with gastric secretion of bicarbonates. Acidosis may contribute to exacerbation of ulcer.
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