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  • Title: The pharmacokinetics and metabolism of sucralose in the rabbit.
    Author: John BA, Wood SG, Hawkins DR.
    Journal: Food Chem Toxicol; 2000; 38 Suppl 2():S111-3. PubMed ID: 10882823.
    Abstract:
    The excretion and metabolism of (14)C-sucralose has been investigated in non-pregnant and pregnant rabbits after administration of single 10mg/kg oral doses. Means of 22% and 55% of the dose were excreted in urine and faeces, respectively, by non-pregnant animals during 5 days. Excretion was similar in pregnant animals with means of 22% and 65% of the dose in urine and faeces, respectively, during the same time. Following a single oral dose, a mean of approximately 7% of the dose was still being excreted during the 96-120-hr collection period. Only one major radioactive component was detected in urine samples which corresponded to unchanged sucralose.
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