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  • Title: [Expression and characterization of HIV-1 Gag p17-p24 protein].
    Author: Li TY, Jin NY, Wang HW, Guo ZR, Fang HH, An RG, Yin Z.
    Journal: Sheng Wu Gong Cheng Xue Bao; 2000 Jan; 16(1):65-8. PubMed ID: 10883279.
    Abstract:
    The biological and immunological characteristics of HIV-1 core protein p17-24 expressed by recombinant vaccinia viruses were studied. The results of indirect immunofluorescence assay (I-IFA), Western blot and dot ELISA showed that the two recombinants could express the p24 gag and p17-24 gag fusion proteins in infected cell lines respectively. The electromicroscope observation revealed that the expressed proteins could also assemble into virus-like particles. The recombinant vaccinia viruses can also stimulate mice for the formation of anti HIV-1 Gag p24 antibody. When infected with the recombinant viruses, the chromosome DNA ladder caused by the apoptosis of the BHK cell was observed.
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