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  • Title: [Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects].
    Author: Golubev MA, Gorodetskiĭ VK, Anis'kina AP, Tochilkin AI, Beliaeva NF.
    Journal: Vopr Med Khim; 2000; 46(2):155-61. PubMed ID: 10885036.
    Abstract:
    The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.
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