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  • Title: Fatal cold anti-i autoimmune haemolytic anaemia complicating hairy cell leukaemia.
    Author: Mainwaring CJ, Walewska R, Snowden J, Winfield DA, Ng JP, Chan-Lam D, Nolan B, Booker DJ, Stamps R, Sokol RJ.
    Journal: Br J Haematol; 2000 Jun; 109(3):641-3. PubMed ID: 10886217.
    Abstract:
    Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder associated with pancytopenia, splenomegaly and the presence of typical hairy B lymphocytes in the bone marrow and/or peripheral blood. The most significant complication relates to opportunistic infections that arise as a consequence of neutropenia and monocytopenia. HCL is occasionally associated with systemic autoimmune disorders including polyarteritis nodosa and rheumatoid disease. Secondary autoimmune haemolytic anaemia (AIHA) appears to be rare. We report on two cases of HCL complicated by fatal cold anti-i AIHA. Fulminant haemolysis causing death is rare in cold AIHA and only a few individual cases have been reported, none having anti-i specificity.
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