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  • Title: Participation of Poly(ADP-ribose)-polymerase of nuclear matrix in DNA repair.
    Author: Zaalishvili TM, Gabriadze IY, Margiani DO, Philauri VR, Surguladze NM.
    Journal: Biochemistry (Mosc); 2000 Jun; 65(6):659-61. PubMed ID: 10887283.
    Abstract:
    The poly(ADP-ribose)-polymerase activity of brain and liver cell nuclei is changed during X-irradiation of rats. In the nuclear matrix, poly(ADP-ribose)-polymerase activity increases at a low dose of irradiation (1.7 Gy) and decreases at a high dose (6.7 Gy). A significant part of the activity of nuclear NMN-adenylyltransferase, a key enzyme for biosynthesis of NAD (the substrate of poly(ADP-ribose)-polymerase), has been found in the nuclear matrix. An interrelation between ADP-ribosylation taking place on the matrix level and eukaryotic cell DNA repair is suggested.
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