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  • Title: Hemoglobin Moabit: alpha 86 (F7) Leu leads to Arg: a new unstable abnormal hemoglobin.
    Author: Knuth A, Pribilla W, Marti HR, Winterhalter KH.
    Journal: Acta Haematol; 1979; 61(3):121-4. PubMed ID: 108887.
    Abstract:
    A new alpha chain abnormal hemoglobin variant was found in a Turkish patient with a mild Heinz body hemolytic anemia and splenomegaly. The substitution alpha 86 Leu leads to Arg, which is next to the heme binding proximal histidine, is responsible for a marked instability of the molecule. The oxygen affinity of the erythrocytes was found to be slightly decreased.
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