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  • Title: Fast echo planar based correlation-peak imaging: demonstration on the rat brain in vivo.
    Author: Mayer D, Dreher W, Leibfritz D.
    Journal: Magn Reson Med; 2000 Jul; 44(1):23-8. PubMed ID: 10893517.
    Abstract:
    Two-dimensional correlation spectroscopy (2D-COSY) was combined with a fast echo planar based spectroscopic imaging technique in a new sequence. It can be optimized according to the coupling patterns of particular metabolites by using a constant time (CT) variant of COSY with chemical shift selective excitation and refocusing. Experiments were performed with an evolution time of 110 ms which was determined by simulating the CT-COSY experiment at several evolution times for the spin systems of myo-inositol (Ins) and taurine (Tau). The sequence has a minimum total measurement time of 17 min and was tested on a spherical phantom filled with a solution of Ins. The in vivo application of this method on the healthy rat brain demonstrates its improved spectral resolution as cross-peak signals from both Ins and Tau can be separated clearly. Magn Reson Med 44:23-28, 2000.
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