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  • Title: Secondary amenorrhoea after oral contraceptives - treatment and follow-up.
    Author: Shearman RP.
    Journal: Contraception; 1975 Feb; 11(2):123-32. PubMed ID: 1089499.
    Abstract:
    103 women with secondary amenorrhea subsequent to oral contraceptive (OC) therapy were studied with regard to previous menstrual history, duration of OC therapy, prospects of spontaneous cure, treatment repsonse, and induced pregnancy's effect on later menstrual pattern. 73 of the 103 patients had regular 26-to-35 day cycles before treatment, and 81 of the 103 had 0 parity. 72 had taken OCs 3 to 24 months with 76 having subsequent amenorrhea of 12 to 23 months. 12 of 22 patients on OCs 25 to 36 months had amenorrhea of 36 months or more. 84 patients had taken 19-nor-gestogen type combination OCs. 61 patients were treated with clomiphene citrate and 34 appeared to ovulated with 24 pregnancies resulting in 22 patients. 7 patients not responding to clomiphene citrate ovulated in response to human pituitary gonadotropin; 4 patients had 6 pregnancies. Follow-up reveals 31 women with persistent amenorrhea, 35 with spontaneous cure, 12 with spontaenous cure after induced pregnancy. The author concluded that induced pregnancy has only a chance effect on ultimate prognosis.
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