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  • Title: [Clinical studies on the effect of drugs used in the treatment of angina].
    Author: Härich B, Hassis R, Immich H, Jeschke D, Kutscha W, Schaumann HJ, Stauch M, Tschirdewahn B.
    Journal: Dtsch Med Wochenschr; 1975 Feb 07; 100(6):215-22. PubMed ID: 1089522.
    Abstract:
    The report is based on a four-centre study on 25 patients with coronary insufficiency (ECG signs). In random sequence the following were given to each patient: a nitrate (isosorbide dinitrate), carbocromene, practolol, and oxyphedrine. The initial criterion for inclusion was S-T depression of 0.2 mV on stepwise exercise (bicycle ergometry). S-T depression, systolic blood pressure and heart rate changes were used as criteria. For each drug there was an acute test and a long-term test of 12 days. The Friedman test was used for the statistical evaluation of the results. Isosorbide dinitrate decreased the extent of S-T depression in the acute tests while practolol did so in the long-term test. Practolol reduced systolic pressure on long-term administration, with no difference in the acute experiment. Heart rate was reduced by practolol both acutely and long-term. These results give no indication for any possible differential treatment of coronary insufficiency, but this may be due to the selection of patients in this study.
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