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  • Title: [Aspirin-induced angioedema of the nape of the neck with naproxen cross-reaction: a case report].
    Author: Ghislain PD, Ghislain E.
    Journal: Ann Med Interne (Paris); 2000 May; 151(3):227-9. PubMed ID: 10896977.
    Abstract:
    We report a case of angioedema limited to the nape of the neck. The symptoms occurred every morning for fifteen days, two or three hours after taking aspirin. The patient took salicylic acid, 100mg per day, orally for two years. The angioedema occurred alone, without urticaria. When aspirin was stopped, the symptoms disappeared. A few weeks later, the patient took napoxen, with occurrence of more pronounced symptoms. The causality score was I3 for both drugs. The most common side-effects of aspirin intake are asthma and urticaria/angioedema. The mechanism of this hypersensitivity is unknown. There are numerous cross-reactions between aspirin and other NSAIDs. This case points out the importance of accurate history taking concerning self-medication for the diagnosis of angioedema.
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