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  • Title: Distribution of carbonic anhydrase isozyme VI in the developing bovine parotid gland.
    Author: Asari M, Miura K, Ichihara N, Nishita T, Amasaki H.
    Journal: Cells Tissues Organs; 2000; 167(1):18-24. PubMed ID: 10899712.
    Abstract:
    The distribution of bovine carbonic anhydrase isozyme VI (CA-VI), purified from bovine saliva, was studied immunohistochemically using antiserum against bovine CA-VI in bovine parotid glands during fetal and postnatal development. A weak expression of CA-VI in undifferentiated epithelial cells and ductal cells was observed in a 4- to 5-month-old fetus with a 26-cm crown-rump length. The reaction in both acinar and ductal cells subsequently persisted during late gestation and birth. Although anti-CA-VI reactivity was still seen in both regions immediately following birth, the reactivity had almost completely disappeared from most duct segments by 1 month following birth. Changes in the localization and time-dependent expression of the isozyme in parotid glands may reflect changes in the biological function of structurally closely related isozymes.
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