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  • Title: Glucagon: role in the hyperglycemia of diabetes mellitus.
    Author: Dobbs R, Sakurai H, Sasaki H, Faloona G, Valverde I, Baetens D, Orci L, Unger R.
    Journal: Science; 1975 Feb 14; 187(4176):544-7. PubMed ID: 1089999.
    Abstract:
    Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.
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